نوع مقاله : مقاله پژوهشی
نویسندگان
مرکز تحقیقات هسته ای سازمان انرژی اتمی ایران.صندوق پستی:3486-11365 تهران, ایران.
چکیده
BNCT، روشی درمانی بر اساس از واکنش بدام‌اندازی نوترون است که برای درمان بدخیمی‌ها مورد استفاده قرار گرفته‌است. این روش بر اساس تمایل برخی از نوکلئیدها برای جذب نوترون‌های حرارتی و تولید یک رادیونوکلئید ناپایدار است که به سرعت فروپاشی شده و ذرات پرانرژی با برد بسیار کوتاه تولید می‌کند. یکی از مهمترین این نوکلئیدها، B10 است که ترکیبات زیادی از آن تهیّه شده و مورد بررسی قرار گرفته‌اند. در این تحقیق سنتز مشتق بورونه گادولینیوم تگزاپیرین (Gd-Tex) که یک مشتق پورفیرین پنج‌دندانه‌ای است برای استفاده در درمان به وسیلة بدام‌اندازی نوترون با استفاده از مشتق‌های بور گزارش شده است. Gd-Tex جزو دستة جدیدی از ترکیبات است که قابلیت آشکارسازی با MRI را دارند. در این کار پژوهشی سنتز همتافت (کمپلکس) حاوی گادولینیوم و دو خوشه بوران برای نشان دادن تأثیر زیاد آن بر BNCT عرضه شده است.
کلیدواژه‌ها
عنوان مقاله [English]
Synthesis of a Boronated Derivative of Gd-Texaphyrine for Potential Use in Boron Neutron Capture Therapy (BNCT)
نویسندگان [English]
- k H. Ebrahimabadi
- R Najafi
چکیده [English]
In the last two decades treatment of brain tumors using BNCT has been performed using improved boron compounds and neutron irradiation techniques. Compounds that make use of carborane clusters, which have a high inherent boron content, should be more effective, provided, of course, the efficient and selective uptake of the boron-containing carrier molecules by cancer or other target cells. Examples of carborane cluster are the icosahedral C2B10H12 carboranes. Many porphyrins and porphyrinoid compounds have demonstrated an ability to selectively accumulate in tumors, and have therefore been considered as the possible candidates for delivery of boron to malignant tissue. The texaphyrins are aromatic pentadentate macro cyclic expanded porphyrins, which have been found to be useful as MRI contrast agents, as radiation sensitizers and in photodynamic theraphy (PDT). In this study, a new boronated texaphyrine for potential use in BNCT has been proposed and synthesized.
کلیدواژه‌ها [English]
- BNCT
- Gd-Tex
- porphyrin
- tumor cells
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