Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

Effect of temperature on the physical specifications of contrast agent in magnetic resonance imaging: chitosan-MnFe2O4 magnetic nanoparticles

Document Type : Research Paper

Authors

A. Khorramdoust 1
M. Ashoor 2
K. Saberyan 3
A. Eidi 1

1 Department of Biology, Science and Research Branch, Islamic Azad University, P.O.Box: 14515-775, Tehran - Iran

2 Radiation Applications Research School, Nuclear Science and Technology Research Institute, AEOI, P.O.Box: 11365-3486, Tehran - Iran

3 Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, AEOI, P.O.Box: 11365-8486, Tehran - Iran

https://doi.org/10.24200/nst.2020.1104
Abstract
In this study, manganese ferrite nanoparticles (MnFe2O4) coated with chitosan (Ch-MnFe2O4) was investigated at different temperatures. We reported the study of synthesis, and characteristics of this superparamagnetic agent, which were well prepared in nano-size via the chemical co-precipitation method. The Ch-MnFe2O4 NPs were annealed at the temperatures of 300, 400 and 500˚C. The structure, morphology, and magnetic properties of the samples were characterized by the X-ray powder diffraction (XRD) and vibrating sample magnetometer (VSM), respectively. The results are indicating that the
Ch-MnFe2O4 NPs are biocompatible, and have a cubic spinel crystal structure. The average sizes of the FA-Ch-MnFe2O4 NPs were found to be dependent on the applied temperature. Also, their sizes as well as the magnetization property will extend as the temperature is increased up to 400˚C. By further increasing the temperature, however, they tend to decrease. These NPs have exhibited uperparamagnetic behavior most likely at the 400˚C temperature. Furthermore, the VSM results have been demonstrated that the number of the magnetic momentums will increase by growing the size, so that they are used as contrast agents and able to affect the relaxation time through the dipole-dipole interaction, which is useful in MRI.

Highlights

1.             R. Thomas, I.K. Park, Y.Y. Jeong, Magnetic iron oxide nanoparticles for multimodal imaging and therapy of cancer, Int. J. Mol. Sci. 14(8), 15910 (2013).

 

2.             C. Liu, Z.J. Zhang, Size-dependent superparamagnetic properties of Mn spinel ferrite nanoparticles synthesized from reverse micelles, Chem. Mater. 13 (6), 2092 (2001).

 

3.             M. Amani, et al. Thermal conductivity measurement of spinel-type ferrite MnFe2O4 nanofluids in the presence of a uniform magnetic field, J. Mol. Liq. 230, 121(2017).

 

4.             C.N. Chinnasamy, et al. Size dependent magnetic properties and cation inversion in chemically synthesized MnFe2O4 nanoparticles, J. Appl. Phys. 101(09), 509 (2007).

 

5.             A.T. Raghavender, N.H. Hong, Dependence of Néel temperature on the particle size of MnFe2O4, J. Mag. Mag. Mater. 323(16), 2145 (2011).

 

6.             M.A. Ahmed, N. Okasha, S.I. El-Dek, Preparation and characterization of nanometric Mn ferrite via different methods, Nanotechnol, 19(6), 1 (2008).

 

7.             H. Li, et al. Carboxymethyl chitosan-folic acid-conjugated Fe3O4-SiO2 as a safe and targeting antitumornanovehicle in vitro. Nanoscale Res. Lett, 9(1), 146 (2014).

 

8.             M.Y. Rafique, et al. Growth of monodisperse nanospheres of MnFe2O4 with enhancedmagnetic and optical properties, Chin. Phys. B, 22(10), 107101 (2013).

 

9.             L. Zeng, et al. Ultrasmall water-soluble metal-iron oxide nanoparticles as T1-weighted contrast agents for magnetic resonance imaging, Phys. Chem. Phys. 14(8), 2631 (2012).

 

10.          M. Goldman, Advances in magnetic resonance: Formal theory of spin–lattice relaxation, J. Mag. Reson. 149, 160 (2001).

 

11.          Y. Jamil, et al. Microwaveassistedsynthesis offine magnetic manganese ferrite particles using co-precipitation technique, Pak. J. Agri. Sci. 45(3), 59 (2008).

 

12.          N.T. Lan, et al. Magnetic properties of MnFe2O4 Ferrite nanoparticles prepared by using co-precipitation, J. Korean Phys. Soc, 52(5) 1522 (2008).

 

13.          S. Yan˜ez-Vilar, et al. A simple solvothermal synthesis of MFe2O4 (M ¼ Mn, CoandNi) nanoparticles, J. Solid State Chem. 182, 2685 (2009).

 

14.          D. Kim, D. Nikles, C. Brazel, Synthesis and characterization of multifunctional Chitosan-MnFe2O4 nanoparticles for magnetic hyperthermia and drug delivery, Mater. 7(3) 4051 (2010).

 

15.          B.D. Cullity, Elements of X-ray Diffraction, (Addison-Wesley Publishing Company, Reading, MA, 1956, P. 259)(1956).

 

16.          S. Sam, A.S. Nesraj, Preparation of MnFe2O4 nanoceramic particles by soft chemical routes, Interna. J. Appl Sci. and Eng. 9(4), 223 (2011).

 

17.          M.G. Naseri et al. Synthesis and characterization of manganeseferrite nanoparticles by thermal treatment method, J. Mag. Mag. Mater. 323(13), 1745 (2011).

Keywords

Manganese ferrite nanoparticles
Chemical Co-precipitation method
Magnetization
Magnetic resonance imaging
1.             R. Thomas, I.K. Park, Y.Y. Jeong, Magnetic iron oxide nanoparticles for multimodal imaging and therapy of cancer, Int. J. Mol. Sci. 14(8), 15910 (2013).
 
2.             C. Liu, Z.J. Zhang, Size-dependent superparamagnetic properties of Mn spinel ferrite nanoparticles synthesized from reverse micelles, Chem. Mater. 13 (6), 2092 (2001).
 
3.             M. Amani, et al. Thermal conductivity measurement of spinel-type ferrite MnFe2O4 nanofluids in the presence of a uniform magnetic field, J. Mol. Liq. 230, 121(2017).
 
4.             C.N. Chinnasamy, et al. Size dependent magnetic properties and cation inversion in chemically synthesized MnFe2O4 nanoparticles, J. Appl. Phys. 101(09), 509 (2007).
 
5.             A.T. Raghavender, N.H. Hong, Dependence of Néel temperature on the particle size of MnFe2O4, J. Mag. Mag. Mater. 323(16), 2145 (2011).
 
6.             M.A. Ahmed, N. Okasha, S.I. El-Dek, Preparation and characterization of nanometric Mn ferrite via different methods, Nanotechnol, 19(6), 1 (2008).
 
7.             H. Li, et al. Carboxymethyl chitosan-folic acid-conjugated Fe3O4-SiO2 as a safe and targeting antitumornanovehicle in vitro. Nanoscale Res. Lett, 9(1), 146 (2014).
 
8.             M.Y. Rafique, et al. Growth of monodisperse nanospheres of MnFe2O4 with enhancedmagnetic and optical properties, Chin. Phys. B, 22(10), 107101 (2013).
 
9.             L. Zeng, et al. Ultrasmall water-soluble metal-iron oxide nanoparticles as T1-weighted contrast agents for magnetic resonance imaging, Phys. Chem. Phys. 14(8), 2631 (2012).
 
10.          M. Goldman, Advances in magnetic resonance: Formal theory of spin–lattice relaxation, J. Mag. Reson. 149, 160 (2001).
 
11.          Y. Jamil, et al. Microwaveassistedsynthesis offine magnetic manganese ferrite particles using co-precipitation technique, Pak. J. Agri. Sci. 45(3), 59 (2008).
 
12.          N.T. Lan, et al. Magnetic properties of MnFe2O4 Ferrite nanoparticles prepared by using co-precipitation, J. Korean Phys. Soc, 52(5) 1522 (2008).
 
13.          S. Yan˜ez-Vilar, et al. A simple solvothermal synthesis of MFe2O4 (M ¼ Mn, CoandNi) nanoparticles, J. Solid State Chem. 182, 2685 (2009).
 
14.          D. Kim, D. Nikles, C. Brazel, Synthesis and characterization of multifunctional Chitosan-MnFe2O4 nanoparticles for magnetic hyperthermia and drug delivery, Mater. 7(3) 4051 (2010).
 
15.          B.D. Cullity, Elements of X-ray Diffraction, (Addison-Wesley Publishing Company, Reading, MA, 1956, P. 259)(1956).
 
16.          S. Sam, A.S. Nesraj, Preparation of MnFe2O4 nanoceramic particles by soft chemical routes, Interna. J. Appl Sci. and Eng. 9(4), 223 (2011).
 
17.          M.G. Naseri et al. Synthesis and characterization of manganeseferrite nanoparticles by thermal treatment method, J. Mag. Mag. Mater. 323(13), 1745 (2011).

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