Document Type : Research Paper

Authors

• A. Rasekholghol ¹
• S.Y. Fazaeli ²
• S. Moradi Dehaghi ¹
• P. Ashtari ²
• M.R. Kardan ³
• A. Joz-Vaziri ³
• Sh. Feizi ²

¹ Faculty of Chemistry, Islamic Azad University, Tehran North Branch, P.O.Box: 165-1153311, Tehran-Iran

² Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, P.O.Box: 11365-3486, Tehran- Iran

³ Reactor research school, Nuclear Science and Technology Research Institute of Iran, AEOI, P.O.Box: 14155-1339, Tehran- Iran

Abstract

In this study, the influence of grafting ¹⁹⁸Au radioisotope on functionalized silica nanoparticles with a the biodistribution of this radioisotope compare to pure gold nanoparticles, was investigated. The Au radioisotope was prepared using neutronic bombardment of a highly pure metallic gold. The prepared radioisotope was coated on silica through an interface ligand. The biodistribution suggested that the hydrophilicity of the ¹⁹⁸Au@MCM-41 nanosilica compare to pure gold nanoparticles was higher. Through the SPECT images and %ID/g measurement, it was found that the excretion of radiotracer from the body compare to pure gold nanoparticles became faster. The Au@MCM-41 nanocomposite could potentially be used in diagnosis and therapy of cancer.

Highlights

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Keywords

• 198Au- radioisotope
• Biodistribution
• Silica nanoparticles