Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

Preparation of gold-198 radioisotope and evaluation of the effect of grafting of 198Au on functionalized silica nanoparticles on its biodistribution: introducing a new theranostic agent

Document Type : Research Paper

Authors

A. Rasekholghol 1
S.Y. Fazaeli 2
S. Moradi Dehaghi 1
P. Ashtari 2
M.R. Kardan 3
A. Joz-Vaziri 3
Sh. Feizi 2

1 Faculty of Chemistry, Islamic Azad University, Tehran North Branch, P.O.Box: 165-1153311, Tehran-Iran

2 Radiation Application Research School, Nuclear Science and Technology Research Institute, AEOI, P.O.Box: 11365-3486, Tehran- Iran

3 Reactor research school, Nuclear Science and Technology Research Institute of Iran, AEOI, P.O.Box: 14155-1339, Tehran- Iran

https://doi.org/10.24200/nst.2021.1301
Abstract
In this study, the influence of grafting 198Au radioisotope on functionalized silica nanoparticles with a the biodistribution of this radioisotope compare to pure gold nanoparticles, was investigated. The Au radioisotope was prepared using neutronic bombardment of a highly pure metallic gold. The prepared radioisotope was coated on silica through an interface ligand. The biodistribution suggested that the hydrophilicity of the 198Au@MCM-41 nanosilica compare to pure gold nanoparticles was higher. Through the SPECT images and %ID/g measurement, it was found that the excretion of radiotracer from the body compare to pure gold nanoparticles became faster. The Au@MCM-41 nanocomposite could potentially be used in diagnosis and therapy of cancer.

Highlights

1.   Y. Wang, et al., Evaluating the Pharmacokinetics and In Vivo Cancer Targeting Capability of Au Nanocages by Positron Emission Tomography Imaging. ACS Nano 6, 5880–5888, 2012.
 
2.    Y. Xu, H. Liu, Z. Cheng, Harnessing the Power of Radionuclides for Optical Imaging: Cerenkov Luminescence Imaging. J. Nucl. Med., 52, 2009–2018, 2011.
 
3.  G. Lucignani, Cerenkov Radioactive Optical Imaging: APromising New Strategy. Eur. J. Nucl. Med. Mol. Imaging  38, 592–595, 2011.
 
4.   D. L. J. Thorek, et al. Cerenkov Imaging: A New Modality for Molecular Imaging. Am. J. Nucl. Med. Mol. Imaging  2, 163–173, 2012.
 
5.    N. Chanda, et al. Radioactive Au Nanostructures in CancerTherapy: Therapeutic Efficacy Studies of GA-198AuNP Nanoconstruct in Prostate Tumor-Bearing Mice. Nanomed.Nanotechnol. 6, 201–209, 2010.
 
6.   Y. Wang, et al.,‌ Radioluminescent Au Nanocages with Controlled Radioactivity for Real-Time In Vivo Imaging. Nano Lett. 2013, 13, 581–585.
 
7.  K. Black, et al., Radioactive 198Au- Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution. ACS Nano 8, 4385-4394, 2014.
 
8.    Y. Fazaeli, et al., In vivo SPECT imaging of tumors by 198,199 Au-labeled graphene oxide nanostructures. Materials Science and Engineering: C. 45, 196-204, 2014.
 
9.  Y. Fazaeli, et al., Grafting of [64Cu]-TPPF20 porphyrin complex on Functionalized nano-porous MCM-41 silica as a potential cancer imaging agent, Applied Radiation and Isotopes. 112, 13-19, 2016.
 
10.   Y. Fazaeli,‌ Z. Asgari, DTPA-Functionalized Nano-Porous MCM-41 Silica: A New Potential Nanoengineered Labeled Composite for Diagnostic Applications. Iranian Journal of Science and Technology, Transactions A: Science. 42, 497–504, 2018.
 
11.  Y. Fazaeli, et al., 68Ga@ pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications. Radiochim Acta, 107,157–164, 2018.
 
12.  I‌. Slowing,‌ B. Trewyn, V.‌ ‌Lin, Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells, J. AM. CHEM. SOC, 128, 14792-14793, 2006.

Keywords

198Au- radioisotope
Biodistribution
Silica nanoparticles
1.   Y. Wang, et al., Evaluating the Pharmacokinetics and In Vivo Cancer Targeting Capability of Au Nanocages by Positron Emission Tomography Imaging. ACS Nano 6, 5880–5888, 2012.
 
2.    Y. Xu, H. Liu, Z. Cheng, Harnessing the Power of Radionuclides for Optical Imaging: Cerenkov Luminescence Imaging. J. Nucl. Med., 52, 2009–2018, 2011.
 
3.  G. Lucignani, Cerenkov Radioactive Optical Imaging: APromising New Strategy. Eur. J. Nucl. Med. Mol. Imaging  38, 592–595, 2011.
 
4.   D. L. J. Thorek, et al. Cerenkov Imaging: A New Modality for Molecular Imaging. Am. J. Nucl. Med. Mol. Imaging  2, 163–173, 2012.
 
5.    N. Chanda, et al. Radioactive Au Nanostructures in CancerTherapy: Therapeutic Efficacy Studies of GA-198AuNP Nanoconstruct in Prostate Tumor-Bearing Mice. Nanomed.Nanotechnol. 6, 201–209, 2010.
 
6.   Y. Wang, et al.,‌ Radioluminescent Au Nanocages with Controlled Radioactivity for Real-Time In Vivo Imaging. Nano Lett. 2013, 13, 581–585.
 
7.  K. Black, et al., Radioactive 198Au- Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution. ACS Nano 8, 4385-4394, 2014.
 
8.    Y. Fazaeli, et al., In vivo SPECT imaging of tumors by 198,199 Au-labeled graphene oxide nanostructures. Materials Science and Engineering: C. 45, 196-204, 2014.
 
9.  Y. Fazaeli, et al., Grafting of [64Cu]-TPPF20 porphyrin complex on Functionalized nano-porous MCM-41 silica as a potential cancer imaging agent, Applied Radiation and Isotopes. 112, 13-19, 2016.
 
10.   Y. Fazaeli,‌ Z. Asgari, DTPA-Functionalized Nano-Porous MCM-41 Silica: A New Potential Nanoengineered Labeled Composite for Diagnostic Applications. Iranian Journal of Science and Technology, Transactions A: Science. 42, 497–504, 2018.
 
11.  Y. Fazaeli, et al., 68Ga@ pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications. Radiochim Acta, 107,157–164, 2018.
 
12.  I‌. Slowing,‌ B. Trewyn, V.‌ ‌Lin, Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells, J. AM. CHEM. SOC, 128, 14792-14793, 2006.

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