In cooperation with the Iranian Nuclear Society

Document Type : Research Paper

Authors

1 Department of Nuclear Engineering, Faculty of Mechanical Engineering, Shiraz University, Shiraz, Iran

2 Radiation Application Research School, Nuclear Science and Technology Research Institute, P. O. Box 11365-3486, Tehran - Iran

3 Radiation Application Research School, Nuclear Science and Technology Research Institute, P. O. Box 14893-836, Tehran - Iran

4 Radiation Application Research School, Nuclear Science and Technology Research Institute, P. O. Box 14839-3486, Tehran - Iran

Abstract

In this study, in order to produce and develop a new diagnostic radiopharmaceutical for the imaging of tumors overexpressed somatostatin receptor, [113mIn]In-DOTATATE labeled compound was prepared in optimal conditions using an in-house generator and its precilinical studies was performed. The final product was obtained with a radiochemical purity of nearly 99% (RTLC and HPLC) and a specific activity of 26.2×1015 Bq/mol. The investigation of the stability of the labeled compound showed a radiochemical purity of more than 96% for at least three hours in PBS buffer and in human blood serum.. The results of the biodistribution and the images assessment of the [113mIn]In-DOTATATE labeled compound in normal mice showed that the organs of the gastrointestinal tract such as the pancreas, stomach and intestine, which have cells expressing the somatostatin receptor, have high uptake.

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