Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

Introduction of radio nanocomposite [89Zr]Zr-CdTe QDs as a PET imaging agent

Document Type : Research Paper

Authors

Sh. Feizi 1
ُS.Y. Fazaeli Hoseini Nezhad, 1
P. Ashtari 1
H. Zare 2
F. Bolourinovin 1

1 Radiation Application Research School, Nuclear Science and Technology Research Institute, P.O.Box: 11365-3486, Tehran – Iran

2 Faculty of Physics, Yazd University, P.O.Box: 8915818411, Yazd - Iran

https://doi.org/10.24200/nst.2024.1535
Abstract
The present study focuses on the performance and biodistribution of cadmium telluride quantum dots labeled with zirconium-89. Synthesis and characterization of cadmium telluride quantum dots, radiolabeling and quality control, and then animal studies including investigating biodistribution, tumor accumulation, how to clear up the radiopharmaceutical from the body and positron emission tomography images have been studied. Cadmium telluride quantum dots with 3 nm dimensions were chemically synthesized. The labeling reaction was performed starting with zirconium chloride and CdTe QDs. In order to evaluate the in vivo behavior of [89Zr]Zr-CdTe QDs and to compare it with zirconium-89 ([89Zr]Zr-Chloride), PET imaging experiments were designed and performed. Immediately after each imaging, the mice were dissected and the biodistribution of the radiopharmaceutical to different organs was evaluated. The results indicated the rapid and targeted accumulation of these radionanoparticles in the tumor. Due to the superior properties of the zirconium-89 radioisotope and appropriate biodistribution, these labeled nanoparticles were introduced as potential nuclear imaging agents.

Highlights

  1. Holland J.P, Sheh Y, Lewis J.S. Standardized methods for the production of high specific-activity zirconium-89, Nucl. Med. Biol. 2009;36(7):729-39.

 

2 Guillou A, Earley D.F, Klingler S, Nisli E, Nüesch L.J, Fay R, Holland J.P. The influence of a polyethylene glycol linker on the metabolism and pharmacokinetics of a 89Zr-radiolabeled antibody. Bioconjugate Chemistry. 2021;32(7):1263-1275.

 

  1. Zhang Y, Zhang Y, Lin Q, Wang T, Shi D, Fu Z, Si Z, Xu Z, Cheng Y, Shi H, Cheng D, Targeting infiltrating myeloid cells in gastric cancer using a pretargeted imaging strategy based on bio-orthogonal diels–alder click chemistry and comparison with 89Zr-labeled anti-CD11b positron emission tomography imaging. Molecular Pharmaceutics. 2022;19(1):246-257.

 

  1. Hapuarachchige S, Si G, Huang C.T, Lesniak W.G, Mease R.C, Guo X, Gabrielson K, Artemov D. Dual-modality PET–SPECT image-guided pretargeting delivery in HER2(+) breast cancer models. Biomacromolecules. 2021;22(11):4606-4617.

 

  1. Chomet M, Van Dongen G.A.M.S, Vugts D.J. State of the Art in radiolabeling of antibodies with common and uncommon radiometals for preclinical and clinical immuno-PET. Bioconjugate Chemistry. 2021;32(7):1315-1330.

 

  1. Graves S.A, Kutyreff C, Barrett K.E, Hernandez R, Ellison P.A, Happel S, Aluicio-Sarduy E, Barnhart T.E, Nickles R.J, Engle J.W. Evaluation of a chloride-based (89)Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin. Nuclear Medicine and Biology. 2018;64-65:1-7.

 

  1. Fischer G, Seibold U, Schirrmacher R, Wängler B, Wängler C. (89)Zr, a radiometal nuclide with high potential for molecular imaging with PET: chemistry, applications and remaining challenges. Molecules. 2013;18(6):6469-6490.

 

  1. Gharghani S, Fazaeli Y, Zare H, Feizi S, Ashtari P, Shahedi Z. Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor. Journal of Radioanalytical and Nuclear Chemistry. 2021;330(3):1137-1145.

 

  1. Cheng L, Kamkaew A, Shen S, Valdovinos H, Barnhart T, Cai W, Liu Z. Chelator-Free 89Zr-labeling of Ultra-small WS2/WOx Quantum Dots for PET Imaging. Journal of Nuclear Medicine. 2016;57(supplement 2):1208.

 

  1. Ai F, Goel S, Zhan Y, Valdovinos H.F, Chen F, Barnhart T.E, Cai W. Intrinsically (89)Zr-labeled Gd(2)O(2)S:Eu nanophosphors with high in vivo stability for dual-modality imaging. American Journal of Translational Research. 2016;8(12):5591-5600.

 

  1. Zhao Y, Shaffer T.M, Das S, Pérez-Medina C, Mulder W.J.M, Grimm J. Near-Infrared Quantum Dot and (89)Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging. Bioconjug Chem. 2017;28(2):600-608.

 

  1. Fazaeli Y, Zare H, Karimi S, Rahighi R, Feizi S. Novel aspects of application of cadmium telluride quantum dots nanostructures in radiation oncology. Applied Physics A. 2017;123(8):1-9.

 

  1. Feizi S, Fazaeli Y, Ashtari P, Shirmardi S.P, Yousefnia H, Aslani G. A new targetry system for production of Zirconium-89 radioisotope with Cyclone-30 cyclotron, Radiochimica Acta. Just Accepted. 2023.

 

  1. Larenkov A, Bubenschikov V, Makichyan A, Zhukova M, Krasnoperova A, Kodina G. Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution. Molecules (Basel, Switzerland). 2019;24(8):1534.

Keywords

Quantum dots
Zirconium-89
Labeling
PET imaging
  1. Holland J.P, Sheh Y, Lewis J.S. Standardized methods for the production of high specific-activity zirconium-89, Nucl. Med. Biol. 2009;36(7):729-39.

 

2 Guillou A, Earley D.F, Klingler S, Nisli E, Nüesch L.J, Fay R, Holland J.P. The influence of a polyethylene glycol linker on the metabolism and pharmacokinetics of a 89Zr-radiolabeled antibody. Bioconjugate Chemistry. 2021;32(7):1263-1275.

 

  1. Zhang Y, Zhang Y, Lin Q, Wang T, Shi D, Fu Z, Si Z, Xu Z, Cheng Y, Shi H, Cheng D, Targeting infiltrating myeloid cells in gastric cancer using a pretargeted imaging strategy based on bio-orthogonal diels–alder click chemistry and comparison with 89Zr-labeled anti-CD11b positron emission tomography imaging. Molecular Pharmaceutics. 2022;19(1):246-257.

 

  1. Hapuarachchige S, Si G, Huang C.T, Lesniak W.G, Mease R.C, Guo X, Gabrielson K, Artemov D. Dual-modality PET–SPECT image-guided pretargeting delivery in HER2(+) breast cancer models. Biomacromolecules. 2021;22(11):4606-4617.

 

  1. Chomet M, Van Dongen G.A.M.S, Vugts D.J. State of the Art in radiolabeling of antibodies with common and uncommon radiometals for preclinical and clinical immuno-PET. Bioconjugate Chemistry. 2021;32(7):1315-1330.

 

  1. Graves S.A, Kutyreff C, Barrett K.E, Hernandez R, Ellison P.A, Happel S, Aluicio-Sarduy E, Barnhart T.E, Nickles R.J, Engle J.W. Evaluation of a chloride-based (89)Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin. Nuclear Medicine and Biology. 2018;64-65:1-7.

 

  1. Fischer G, Seibold U, Schirrmacher R, Wängler B, Wängler C. (89)Zr, a radiometal nuclide with high potential for molecular imaging with PET: chemistry, applications and remaining challenges. Molecules. 2013;18(6):6469-6490.

 

  1. Gharghani S, Fazaeli Y, Zare H, Feizi S, Ashtari P, Shahedi Z. Gallium-68 labeled Gd-CdTe quantum dots: a novel nuclear imaging agent for detection of fibrosarcoma tumor. Journal of Radioanalytical and Nuclear Chemistry. 2021;330(3):1137-1145.

 

  1. Cheng L, Kamkaew A, Shen S, Valdovinos H, Barnhart T, Cai W, Liu Z. Chelator-Free 89Zr-labeling of Ultra-small WS2/WOx Quantum Dots for PET Imaging. Journal of Nuclear Medicine. 2016;57(supplement 2):1208.

 

  1. Ai F, Goel S, Zhan Y, Valdovinos H.F, Chen F, Barnhart T.E, Cai W. Intrinsically (89)Zr-labeled Gd(2)O(2)S:Eu nanophosphors with high in vivo stability for dual-modality imaging. American Journal of Translational Research. 2016;8(12):5591-5600.

 

  1. Zhao Y, Shaffer T.M, Das S, Pérez-Medina C, Mulder W.J.M, Grimm J. Near-Infrared Quantum Dot and (89)Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging. Bioconjug Chem. 2017;28(2):600-608.

 

  1. Fazaeli Y, Zare H, Karimi S, Rahighi R, Feizi S. Novel aspects of application of cadmium telluride quantum dots nanostructures in radiation oncology. Applied Physics A. 2017;123(8):1-9.

 

  1. Feizi S, Fazaeli Y, Ashtari P, Shirmardi S.P, Yousefnia H, Aslani G. A new targetry system for production of Zirconium-89 radioisotope with Cyclone-30 cyclotron, Radiochimica Acta. Just Accepted. 2023.

 

  1. Larenkov A, Bubenschikov V, Makichyan A, Zhukova M, Krasnoperova A, Kodina G. Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution. Molecules (Basel, Switzerland). 2019;24(8):1534.

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