In cooperation with the Iranian Nuclear Society

Document Type : Research Paper

Authors

1 Assistant Professor

2 Radiation Application Research School, Nuclear Science and Technology Research Institute, P.O.BOX: 1439951113, Tehran, Iran.

3 No

Abstract

Albumin particles are used in nuclear medicine as carriers of diagnostic and therapeutic radionuclides. For this purpose, these particles were prepared using temperature. After size determination, the particles were labeled with gamma irradiated radionuclide 99mTc in the presence of stannous chloride as a reducing agent. Radiochemical purity was determined by chromatography methods. For labeled particles, stability in normal saline and biodistribution in normal and glioma tumorized rat were determined. The size of particles was determined in the range below 50 nm. Radiochemical purity of more than 98% was obtained. Evaluation of labeled particles stability showed a radiochemical purity of more than 90% during 6 hr in saline and human serum solutions. The results of biodistribution studies determined liver and tumor uptake followed by high kidneys washout. Gamma imaging scintigraphy in rat, showed tumor and kidneys. The results confirmed the ability of labeled particles as a tumor diagnostic radiopharmaceutical.

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