Document Type : Research Paper
Authors
- Mahdi Gholamhosseini-Nazari
- Ali Rahiminezhad
- Meghdad Gilani
- Miad Hahsemizadeh
- Hojjat Masoumi
- Rahim Sardari
- Hossein Naderi
Pars Isotope Company
Abstract
Galium-68 (68Ga) is one of the radionuclides that is widely used for diagnostic purposes in Nuclear Medicine. Due to the availability of 68Ge/68Ga generators, the interest of the radiopharmaceutical industry is currently focused on the development of this generator. Therefore, the development and application of 68Ge/68Ga generators is still a hot topic in nuclear medicine. During the last years in Iran, Pars Isotope Company has produced 68Ge/68Ga generators (Pars-GalluGen generator). This generator was eluted with 5 ml of 0.6 M hydrochloric acid. In continue, Pars Isotope has produced the second generation of Pars-GalluGen generators. This generator is based on SnO2-TiO2 resin matrix and milked with 0.1 M hydrochloric acid. In this research, the main characteristics of the second generation of Pars-GalluGen generators were determined and its quality control was evaluated. The obtained results indicate that this generator has all specifications of the European Pharmacopoeia for use and has better performance characteristics such as higher chemical, radiochemical, and radionuclide purity and also higher elution yield compared to the first generation.
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