Document Type : Research Paper
Authors
1 Medical Radiation Engineering Department, Science and Research Branch, Islamic Azad University, P.O. Box: 14515-775, Tehran-Iran
2 radioactive waste companyMedical Radiation Engineering Department, Science and Research Branch, Islamic Azad University, P.O. Box: 14515-775, Tehran-Iran
3 Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Box 14395-836, Tehran, Iran.
Abstract
Among promising radio lanthanides, 132/135La stands out as a theranostic pair, offering specific advantages for the preparation of a wide range of radiopharmaceuticals. In this study, to produce the theranostic pair 132/135La through the interaction natBa(p,x)13xLa, theoretical calculations were performed using the nuclear codes ALICE-91, TALYS-1.8, and SRIM-2013. Then, the natural barium target was irradiated in a 30 MeV cyclotron with 22.5 MeV protons and a current of 100 μAh. After the separation of lanthanum from the irradiated target, the chemical purity, radiochemical purity, and radionuclide purity of the solution were examined using ICP-OES, RTLC, and gamma spectrometry, respectively. Finally, the effect of increasing the concentration of the chelator DOTA (1-100 nanomolar) on the labeling of the chelator with lanthanum was investigated. The results showed that the average total amount of metal ions in the final solution was less than 0.1 ppm, and the radiochemical and radionuclide purities were above 99% and 99.5%, respectively. The labeling of the chelator DOTA with lanthanum demonstrated that even with the addition of 1 nmol of this chelator, a radiochemical purity higher than 93% was achieved. This study indicated that It is possible to produce lanthanum radionuclides with the required quality for the development of theranostic radiopharmaceuticals.
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