Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

The Study of 201TlCl Short-Term Effects on Rat Serum Factors

Document Type : Research Paper

Authors

A.R Jalilian
M Alinejad
Abstract
Tl-201 administration for cardial scan using SPECT has been performed for more than 4 decades, while in Iran it has been produced and used for 17 years. Although this radiopharmaceutical is injected at sub-pharmacological doses to the patients, there has been no documented research on the short-term effects on the tissues such as heart and liver, according to the best of our knowledge. In this work, the radiopharmaceutical effects on hepatic serum factors such as, billirubin (BN), alkaline phosphatase (AP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) have been investigated. The experiments were performed for periods of 1, 4 and 24 hours post injection of the tracer to 12 rats in each group in comparison with the negative control group. The results demonstrated a slight serum BN difference in two groups, while significant differences in serum AST, ALT and AP were detected. The results of this study offer some valuable information on the serum biochemical factors and Tl-201 administration relationship which is not only important in the interpretation of the clinical biochemistry tests, but also would impose limitations on the application of this tracer in patients with hepatic disorders. Further investigations on the human patients must be conducted.
 

Highlights

  1. 1.    http://en. wikipedia.org/wiki/NaKATPase

 

  1. 2.    ح. محتشمی، ”بهینه‌سازی تولید تالیم- 201 از طریق پرتودهی تالیم- 203 با حداکثر جریان ممکن و بررسی مسایل انتقال حرارت بر روی هدف،“ پایان‌نامه کارشناسی ارشد مهندسی هسته‌ای، پرتوپزشکی (1377-1376).                                                        

 

  1. 3.    http://halibm.hp.infoseek.co.jp/ExMyoTl.htm.

 

  1. 4.    ر. مک‌پرسون، م. پین‌کاس، بیوشیمی بالینی، مترجمین سالار بختیاری و ... ، تهران، اندیشه رفیع (1386).

 

  1. 5.    www.amarillomed.com.

 

  1. 6.    http://www.drugs.com.enc.bilirubin.html.

 

  1. 7.    David K. Weber, Kathleen Danielson, Stan Wright, Janet E. Foley, “Hematology and serum biochemistry values of dusky-footed wood rat (neotoma fuscipes),” Journal of Wildlife Diseases, 38(3), 576-582 (2002).

 

 

 

  1. 8.    Nwangwu Spencer, Adeyekun Felix, Uhunmwangho S. Esosa, Madu Michael, Ofusori David, Nwangwu Udoka4, Njoya Helen1, J. Josiah, “SundayHaemolytic effects and changes in serum enzymes in normal rats exposed to halofantrine hydrochloride Overdose,” African Journal of Pharmacy and Pharmacology, Vol. 3(11), 556-559 (2009).

 

  1. 9.    http://www.drkaslow.com/html/alkaline_phosphatase.html.

 

10. S. Reitman and S. Frankel, “Acolorimetric method for the determination of serum glutamic oxaloacetic & glutamic pyruvic trans aminases,” Am. J. Clin. Pathol, 28:57-63 (1957).

 

11. Auger Electron Dosimetry, AAPM Report, No. 37 (1993).

Keywords

201TlCl
Billirubin
Alkaline Phosphatase
Aspartate Aminotransferase
Alanine Aminotransferase
  1. 1.    http://en. wikipedia.org/wiki/NaKATPase

 

  1. 2.    ح. محتشمی، ”بهینه‌سازی تولید تالیم- 201 از طریق پرتودهی تالیم- 203 با حداکثر جریان ممکن و بررسی مسایل انتقال حرارت بر روی هدف،“ پایان‌نامه کارشناسی ارشد مهندسی هسته‌ای، پرتوپزشکی (1377-1376).                                                        

 

  1. 3.    http://halibm.hp.infoseek.co.jp/ExMyoTl.htm.

 

  1. 4.    ر. مک‌پرسون، م. پین‌کاس، بیوشیمی بالینی، مترجمین سالار بختیاری و ... ، تهران، اندیشه رفیع (1386).

 

  1. 5.    www.amarillomed.com.

 

  1. 6.    http://www.drugs.com.enc.bilirubin.html.

 

  1. 7.    David K. Weber, Kathleen Danielson, Stan Wright, Janet E. Foley, “Hematology and serum biochemistry values of dusky-footed wood rat (neotoma fuscipes),” Journal of Wildlife Diseases, 38(3), 576-582 (2002).

 

 

 

  1. 8.    Nwangwu Spencer, Adeyekun Felix, Uhunmwangho S. Esosa, Madu Michael, Ofusori David, Nwangwu Udoka4, Njoya Helen1, J. Josiah, “SundayHaemolytic effects and changes in serum enzymes in normal rats exposed to halofantrine hydrochloride Overdose,” African Journal of Pharmacy and Pharmacology, Vol. 3(11), 556-559 (2009).

 

  1. 9.    http://www.drkaslow.com/html/alkaline_phosphatase.html.

 

10. S. Reitman and S. Frankel, “Acolorimetric method for the determination of serum glutamic oxaloacetic & glutamic pyruvic trans aminases,” Am. J. Clin. Pathol, 28:57-63 (1957).

 

11. Auger Electron Dosimetry, AAPM Report, No. 37 (1993).

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