Silica-Gel Modified with Zirconium Oxide as a Novel 99Mo Adsorbent in 99mTc Generators

Salehi, H; Mollarazi, E; Abbasi, H

Silica-Gel Modified with Zirconium Oxide as a Novel 99Mo Adsorbent in 99mTc Generators

Document Type : Research Paper

Authors

H Salehi

E Mollarazi

H Abbasi

Abstract

A new ⁹⁹Mo adsorbent has been prepared with modified silica gel with zirconium oxide (SiO₂/ZrO₂:Na₂MoO₄) and used in technetium-99m generator. The adsorption behaviors of ⁹⁹Mo in the form of molybdate and ^99mTc in the form of pertechnetate on the new adsorbent was investigated showed that the adsorption capacity of molybdate on this generator was considerably higher than the usual generator with alumina column. Coating zirconium oxide on the surface of silica gel resulted in higher ⁹⁹Mo adsorption of this compound. ^99mTc is eluted with 0.9% NaCl, and the radionuclidic, radiochemical and chemical purities of the eluate were checked. This generator has a great potential as compared to the traditional alumina generators.

Highlights

1. M. Tubis, W, Wolf, “Radiopharmacy, Jhon Wiley and Sons; New York,” 263 (1976).

2. G.B. Saha, “Fundamentals of nuclear pharmacy,” Springer, Cleveland (1998).

3. R.E. Weiner, M.L. Thakur, “Metalic radionuclides: Application in diagnostic and therapeutic nuclear medicine,” Radiochim. Acta. 70/71, 273 (1995).

4. J.A. Osso Jr, “⁷⁷Br isotope production for medical use, Tese (Doutorado), University of Manchester, London,” (1986).

5. V. Rarnic, B. Georenc, J. Novak, Atompraxis, 13: 258 (1967).

6. L. Lindner, “Anion Exchange On Iron Hydroxide Report,” KFK-216 (1963).

7. S. Meloni, A. Brandon, “A new technetium-99m generator using manganes dioxide,” Int. J. Appl. Radiat. Isot. 19: 164 (1988).

8. Y. Maki, Y. Murakami, “^99mTc generator by use of silica gel as adsorbent,” Nippon Kagaku Zasshi, 92: 12, 1211, Jan 01 (1971).

9. M.T. El-Kolaly, N.Z. Misak, “A ^99mTc generator based on the adsorption of ⁹⁹Mo Molybdophosphate on hydrous manganes dioxide “Nucl. Med. Biol,” 15: 664 (1988).

10. V.I. Levin, L.S. Kozyreva-Alexandra, T. Sokolova, “A new ^99mTc generator of higher activity,” Int. J. Appl. Radiat. Isot, 30: 450 (1979).

11. M. Yamashita, S.S. Rosatto, L.T. Kubota, “Electrochemical Comparative Study of Riboflavin, FMN and FAD Immobilized on the Silica Gel Modified with Zirconium Oxide,” J. Braz. Chem. Soc, 13, 635 (2002).

12. Dominick, A. Desantis, Hillsborough, Robert A. Paul, “Zirconium silica hydrogel compositions and methods of preparation,” U.S. Patent, 5069816, (1991).

13. British Pharmacopoeia 2, 24532 (2000).

Keywords

Technetium-99m Generator

Molybdenium-99

Chromatography

Zirconium Oxides

1. 1. M. Tubis, W, Wolf, “Radiopharmacy, Jhon Wiley and Sons; New York,” 263 (1976).
1. 2. G.B. Saha, “Fundamentals of nuclear pharmacy,” Springer, Cleveland (1998).
1. 3. R.E. Weiner, M.L. Thakur, “Metalic radionuclides: Application in diagnostic and therapeutic nuclear medicine,” Radiochim. Acta. 70/71, 273 (1995).
1. 4. J.A. Osso Jr, “⁷⁷Br isotope production for medical use, Tese (Doutorado), University of Manchester, London,” (1986).
1. 5. V. Rarnic, B. Georenc, J. Novak, Atompraxis, 13: 258 (1967).
1. 6. L. Lindner, “Anion Exchange On Iron Hydroxide Report,” KFK-216 (1963).
1. 7. S. Meloni, A. Brandon, “A new technetium-99m generator using manganes dioxide,” Int. J. Appl. Radiat. Isot. 19: 164 (1988).
1. 8. Y. Maki, Y. Murakami, “^99mTc generator by use of silica gel as adsorbent,” Nippon Kagaku Zasshi, 92: 12, 1211, Jan 01 (1971).
1. 9. M.T. El-Kolaly, N.Z. Misak, “A ^99mTc generator based on the adsorption of ⁹⁹Mo Molybdophosphate on hydrous manganes dioxide “Nucl. Med. Biol,” 15: 664 (1988).
1. 10. V.I. Levin, L.S. Kozyreva-Alexandra, T. Sokolova, “A new ^99mTc generator of higher activity,” Int. J. Appl. Radiat. Isot, 30: 450 (1979).
1. 11. M. Yamashita, S.S. Rosatto, L.T. Kubota, “Electrochemical Comparative Study of Riboflavin, FMN and FAD Immobilized on the Silica Gel Modified with Zirconium Oxide,” J. Braz. Chem. Soc, 13, 635 (2002).
12. Dominick, A. Desantis, Hillsborough, Robert A. Paul, “Zirconium silica hydrogel compositions and methods of preparation,” U.S. Patent, 5069816, (1991).
1. 13. British Pharmacopoeia 2, 24532 (2000).