Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

Design and Fabrication of a Suitable Target for 87Y Production

Document Type : Research Paper

Authors

M Ghasemi
M Mirzaei
B Fateh
A Mosavi Zarandi
G Aslani
N Shadanpoor
P Roshan Farzad
M Ensaf
Abstract
87Y/87mSr generator is widely used in nuclear medicine. 87mSr(2.8h,Eγ=388keV) and the parent isotope 87Y(80.3h,Eγ=484keV) are used for skeletal scintigraphy and dosimetry modeling.Theoretical studies of cross section indicated that 88Sr(p.2n)87Y reaction in a cyclotron appears to be an attractive way for high production of 87Y. The aim of this study is to design and fabricate a suitable target for the above reaction. A software in C language has been written to calculate the products yields, and to determine the optimum energy of proton (21-27MeV) and the target thickness in order to get a maximum yield for 87Y and a minimum yield for the rest of products. An increase of yield from 0.41mCi/μA.h for Sr(NO3)2 target to 0.57mCi/μA.h for ClSr2 target has been achieved. This gain can be due to the following reasons:i) better heat transfer from the target to the cooling system (with optimizing the target holder),ii) higher melting point of target, iii) increase of Sr weight percent in the target, iv) more activity because of  keeping the target surface cool.

Highlights

  1. 1.    E. Leicht, R. Berberich, “Tumoral calcinosis: accumulation of bone-seeking tracers in the calcium deposits,” Eur. J. Nucl. Med, Vol.4, 419-421(1979).

 

  1. 2.    K. Schomacker, B. Hientzsch, “Biokinetics of tumor-affinity yttrium preparations,” Nuclear Medicine (1995).

 

  1. 3.    Prashant, K. Rohatgi, “Strontium 87m lung scans in pulmonary aspergillosis,” AMJ Roentgenol, Vol.129, 879-882 (1977).

 

  1. 4.    G. Sgouros, “Yttrium-90 biodistribution by yttrium-87 imaging: a theoretical feasibility analysis,” Med Phys (1998).

 

  1. 5.    Ziegler, J.F. Biersack, Littmark “The stopping and range of ions in solids,” (1985).

 

  1. 6.    A.G.M. Janssen, R.A.M.J. Claessens, “A rapid and high-yield preparation method for 87Y/87mSr generator, using the 88Sr(p,2n) reaction,” Department of physics, Eindhoven university of technology, Appl. Radi. Isot. Vol.37, 297-303 (1986).

 

  1. 7.   

 

mSr87
 

 

م.ر. قاسمی، پایان نامه کارشناسی ارشد، ”طراحی وساخت هدف مناسب جهت تهیه           برای مصارف پزشکی،“ دانشکده فیزیک و علوم هسته‌ای، دانشگاه صنعتی امیرکبیر (1382).                        

 

 

 

 

 

 

 

 

 

  1. 8.    S.M. Haji saeid, Afarideh-H, “The NRCAM cyclotron facilities,” Cyclotrons and their applications,” New Jersey, World Scientific, 128-131 (1995).

 

  1. 9.    Wu-long Cheng, Ai-Ren Lo, “A simple and rapid method for the preparation of 87Y/87mSr generator,” Institute of Nuclear Energy Research Atomic Energy, Council, Vol.245, 31-36 (2000).

 

  1. 10.              Yoshio Homma, Michiko Ishii, “Excitation function and yields for the production of 87mY and preparation of a 87mSr generator,” Inter. Journal of App. Radiation and Isotopes, Vol. 31, 399-403 (1980).

 

  1. 11.              Richard, B. Firestone, “Table of isotopes CD-Rom “Lawrence Berkley N.L.university of California (1996).

 

  1. 12.              S. Krane-Kenneth, “Introductory Nuclear Physics,” John wiley & sons, New York (1988).

 

  1. 13.              D.R. Sachdev, N.T. Porile, L. Yaffe, “Reaction of Sr-88 with protons of energies 7-85 MeV,” EXFOR (1967).

 

  1. 14.              S.M. Qaim “Nuclear data for medical applications,” Radiochemistry. Acta, Vol.89, 89-196 (2001).

 

Keywords

Cyclotron
Proton
Yttrium
Yield
Cross Section
  1. 1.    E. Leicht, R. Berberich, “Tumoral calcinosis: accumulation of bone-seeking tracers in the calcium deposits,” Eur. J. Nucl. Med, Vol.4, 419-421(1979).

 

  1. 2.    K. Schomacker, B. Hientzsch, “Biokinetics of tumor-affinity yttrium preparations,” Nuclear Medicine (1995).

 

  1. 3.    Prashant, K. Rohatgi, “Strontium 87m lung scans in pulmonary aspergillosis,” AMJ Roentgenol, Vol.129, 879-882 (1977).

 

  1. 4.    G. Sgouros, “Yttrium-90 biodistribution by yttrium-87 imaging: a theoretical feasibility analysis,” Med Phys (1998).

 

  1. 5.    Ziegler, J.F. Biersack, Littmark “The stopping and range of ions in solids,” (1985).

 

  1. 6.    A.G.M. Janssen, R.A.M.J. Claessens, “A rapid and high-yield preparation method for 87Y/87mSr generator, using the 88Sr(p,2n) reaction,” Department of physics, Eindhoven university of technology, Appl. Radi. Isot. Vol.37, 297-303 (1986).

 

  1. 7.   

 

mSr87
 

 

م.ر. قاسمی، پایان نامه کارشناسی ارشد، ”طراحی وساخت هدف مناسب جهت تهیه           برای مصارف پزشکی،“ دانشکده فیزیک و علوم هسته‌ای، دانشگاه صنعتی امیرکبیر (1382).                        

 

 

 

 

 

 

 

 

 

  1. 8.    S.M. Haji saeid, Afarideh-H, “The NRCAM cyclotron facilities,” Cyclotrons and their applications,” New Jersey, World Scientific, 128-131 (1995).

 

  1. 9.    Wu-long Cheng, Ai-Ren Lo, “A simple and rapid method for the preparation of 87Y/87mSr generator,” Institute of Nuclear Energy Research Atomic Energy, Council, Vol.245, 31-36 (2000).

 

  1. 10.              Yoshio Homma, Michiko Ishii, “Excitation function and yields for the production of 87mY and preparation of a 87mSr generator,” Inter. Journal of App. Radiation and Isotopes, Vol. 31, 399-403 (1980).

 

  1. 11.              Richard, B. Firestone, “Table of isotopes CD-Rom “Lawrence Berkley N.L.university of California (1996).

 

  1. 12.              S. Krane-Kenneth, “Introductory Nuclear Physics,” John wiley & sons, New York (1988).

 

  1. 13.              D.R. Sachdev, N.T. Porile, L. Yaffe, “Reaction of Sr-88 with protons of energies 7-85 MeV,” EXFOR (1967).

 

  1. 14.              S.M. Qaim “Nuclear data for medical applications,” Radiochemistry. Acta, Vol.89, 89-196 (2001).

 

Home