Assessment of Biodistribution of 131-IPPA in Cardiac and  Non-Cardiac Tissues in Laboratory Animals by Imaging

Moradkhani, S; Sadadi, F; Matluobi, M; Jalilian, A.R; Shafaie, K; Karimian, A.R; Daneshvari, S

Assessment of Biodistribution of 131-IPPA in Cardiac and Non-Cardiac Tissues in Laboratory Animals by Imaging

Document Type : Research Paper

Authors

S Moradkhani

F Sadadi

M Matluobi

A.R Jalilian

K Shafaie

A.R Karimian

S Daneshvari

Abstract

The main substrate of myocardial metabolism is fatty acids which constitutes the principal agent for myocardial consumption and provides almost 60-80% of the energy utilized by the heart in the resting state. Evaluation of cardiac metabolism is important for the assessment of some of cardiac disorders such as Ischemic Heart disease (IHD), cardiomyopathy (functional disorders) and Hypertensive cardiac disorders. Today, almost in all of the developed countries, PET is the first step for diagnosis and assessment of cardiac metabolic disorders. It is, however, too expensive to be used in all centers and are not available in all countries. In this regards, 123-IPPA was introduced as a substitute of PET system for evaluation of cardiac function (metabolism) and it is a complementary method for other Para-clinical methods. We decided to have a preliminary study on IPPA and due to the lack of 123-I, we had to use 131-I. The labeling of IPPA by 131-I, purification and sterilization of 131-IPPA done by the Chemistry Group of Cyclotron Ward and the bio-kinetic and imaging of rat, mice (Laboratory Animals) were performed in the Nuclear Medicine Group. After injection of a proper dose of this radiotracer, the imaging was performed in an appropriate time. In our first images, there were intensive accumulation of tracer in animals' thyroid glands, though after the intake of Lugol solution, the thyroid did not appeare and we had a number of excellent images of animal heart that was the target organ.

Highlights

S.N. Reske “Metabolism of 15 (P¹²³I iodophenyl-) pentadecanoic acid in heart muscle and non cardiac tissues,” E.J. Nucl. Med 10:228-234 (1985).
P.R. Franken “Abnormal free fatty acid uptake in subacute myocardial infarction after coronary thrombolysis,” J. Nucl. Med 35 (11): 1758-1765 (1994).
P. Chouraqui “Comaprison of myocardial imaging with iodine-123- iodophenyl -9 methyl pentadecanoic acid and thallium 201chloride for assessment of patients with exercise induced myocardial ischemia,” J. Nucl. Med 32 (3): 447-452 (March 1991).
I. Matsunari “Kinetics of ¹²³I-BMIPP in patients with prior myocardial infarction: Assessment with dynamic rest and stress images compared with stress thallium 201 SPECT,” J. Nucl. Med 35 (8): 1279-1285 (August 1994).
J. Kropp “Single photon emission tomography imaging of myocardial oxidative metabolism with 15-(p[¹²³I] iodophenyl) pentadecanoic acid and aorta-coronary bypass graft surgery,” E.J. Nucl. Med 18:467-474 (1991).
H.J. Machulla “Synthesis of radioiodinated phenyl fatty acids for studying myocardial metabolism,” Journal of radiopharmaceutical Chemistry, 56(1): 253-261 (1980).
W.S. Richter “Combined thallium -201 and dynamic iodine-123 iodophenyl pentadecanoic acid single–photon emission computed tomography in patients after acute myocardial infarction with effective reperfusion: Clin.Cardiol,” 23(12): 902-908 (Dec 2000).
H. Seki “Prediction of functional improvement of ischemic myocardium with (123I-BMIPP SPECT and 99mTc-tetrofosmin SPECT imaging: a study of patients with large acute myocardial infarction and receiving revascularization therapy,” Cir. Journal, 69(3): 311-9 (March 2005).
H.J. Machulla “Biochemical and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium,”E.J. Nucl. Med. 5:171-173 (1980).

K. Watanabe, “Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina,” J. Nucl. Med 43(11):1476-81 (Nov 2002).

Keywords

Free Fatty Acid

131–IPPA

Cardiac Metabolism

Biological Distribution

Thyroid Uptake

S.N. Reske “Metabolism of 15 (P¹²³I iodophenyl-) pentadecanoic acid in heart muscle and non cardiac tissues,” E.J. Nucl. Med 10:228-234 (1985).
P.R. Franken “Abnormal free fatty acid uptake in subacute myocardial infarction after coronary thrombolysis,” J. Nucl. Med 35 (11): 1758-1765 (1994).
P. Chouraqui “Comaprison of myocardial imaging with iodine-123- iodophenyl -9 methyl pentadecanoic acid and thallium 201chloride for assessment of patients with exercise induced myocardial ischemia,” J. Nucl. Med 32 (3): 447-452 (March 1991).
I. Matsunari “Kinetics of ¹²³I-BMIPP in patients with prior myocardial infarction: Assessment with dynamic rest and stress images compared with stress thallium 201 SPECT,” J. Nucl. Med 35 (8): 1279-1285 (August 1994).
J. Kropp “Single photon emission tomography imaging of myocardial oxidative metabolism with 15-(p[¹²³I] iodophenyl) pentadecanoic acid and aorta-coronary bypass graft surgery,” E.J. Nucl. Med 18:467-474 (1991).
H.J. Machulla “Synthesis of radioiodinated phenyl fatty acids for studying myocardial metabolism,” Journal of radiopharmaceutical Chemistry, 56(1): 253-261 (1980).
W.S. Richter “Combined thallium -201 and dynamic iodine-123 iodophenyl pentadecanoic acid single–photon emission computed tomography in patients after acute myocardial infarction with effective reperfusion: Clin.Cardiol,” 23(12): 902-908 (Dec 2000).
H. Seki “Prediction of functional improvement of ischemic myocardium with (123I-BMIPP SPECT and 99mTc-tetrofosmin SPECT imaging: a study of patients with large acute myocardial infarction and receiving revascularization therapy,” Cir. Journal, 69(3): 311-9 (March 2005).
H.J. Machulla “Biochemical and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium,”E.J. Nucl. Med. 5:171-173 (1980).

K. Watanabe, “Myocardial sympathetic denervation, fatty acid metabolism, and left ventricular wall motion in vasospastic angina,” J. Nucl. Med 43(11):1476-81 (Nov 2002).