Document Type : Research Paper
Authors
Abstract
Selenium-75 was prepared in no-carrier-added elemental form by proton bombardment of a compressed natural arsenous trioxide disc. The chemical separation process was performed using solvent-solvent extraction method, which resulted in the extraction of selenium in organic phase. After the initial spectroscopic analysis, elemental selenium was oxidized to [75Se] selenium dioxide and reacted with ethyl acetoacetate semicarbazone in acetic acid as the solvent to produce [75Se]- 5- ethoxycarbonyl - 4- methyl-1, 2, 3- selenadiazole as a prototype. The labeled compound was purified by chemical methods and quality control tests (radionuclidic, radiochemical, chemical purity and apyrogenicity-sterility tests) were performed, which confirmed the optimum purity of the final product.
Highlights
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Keywords
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