Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

The Effect of Radiosterilization on Surface Properties of Polyurethane Film

Document Type : Research Paper

Author

N Sheikh
Abstract
In this paper the effect of sterilization method by gamma-ray on structure and cytotoxicity  of polyurethane film surface has been investigated. For this purpose reactive urethane prepolymer was synthesized by the reaction between TDI with a mixture of PEG and Castor oil (50/50, w/w). The cured prepolymer films were prepared due to the reaction of reactive prepolymer with air moisture under ambient conditions. The polyurethane films were sterilized by gamma-ray (25 kGy). The surface structure of sterilized polyurethane film was observed by SEM and compared to that of the unsterilized film. Also, the in vitro interaction of fibroblast L929 cells and sterilized polyurethane film was evaluated. Results showed no signs of cell toxicity.  

Highlights

  1. R. M. Streicher, “Sterilization and long-term aging of medical grade UHMWPE,” Radiat. Phys. Chem., 46, 4-6, 893 (1995).

     

  2. Plastics design library, “The effect of sterilization methods on plastics and elastomers,” New York, p. IV (1994).

     

  3. S. Corneillie, P. Lan, E. Schacht, M. Davies, “Polyethylene glycol-containing polyurethanes for biomedical applications,” Polymer International, 46, 251-259 (1998).

     

  4. E. L. McCaffery, “Laboratory preparation for macromolecular chemistry,” McGraw Hill Inc., New York (1970).

  5. D. J. David And H. B. Staley, “Analytical chemistry of the polyurethanes,” Wiley interscience, New York, V. XVI, part III (1969).

     

  6. N. Szycher, “Szycher’s handbook of polyurethanes,” CRC Press, New York (1999).    

     

  7. N. Hasirci and A. Burke, “A novel polyurethane film for biomedical use,” Journal of Bioactive and Compatible Polymers, 2, 131 (1987).

     

  8. D. R. Owen and R. M. Zone, in “Encyclopedia of materials science and engineering,” edited by M. Bever, Pergamon Press, Oxford, 5, 3799 (1986).      

Keywords

sterilization
gamma-ray
polyurethane film
cytotoxicity
fibroblast cell

  1. R. M. Streicher, “Sterilization and long-term aging of medical grade UHMWPE,” Radiat. Phys. Chem., 46, 4-6, 893 (1995).

     

  2. Plastics design library, “The effect of sterilization methods on plastics and elastomers,” New York, p. IV (1994).

     

  3. S. Corneillie, P. Lan, E. Schacht, M. Davies, “Polyethylene glycol-containing polyurethanes for biomedical applications,” Polymer International, 46, 251-259 (1998).

     

  4. E. L. McCaffery, “Laboratory preparation for macromolecular chemistry,” McGraw Hill Inc., New York (1970).

  5. D. J. David And H. B. Staley, “Analytical chemistry of the polyurethanes,” Wiley interscience, New York, V. XVI, part III (1969).

     

  6. N. Szycher, “Szycher’s handbook of polyurethanes,” CRC Press, New York (1999).    

     

  7. N. Hasirci and A. Burke, “A novel polyurethane film for biomedical use,” Journal of Bioactive and Compatible Polymers, 2, 131 (1987).

     

  8. D. R. Owen and R. M. Zone, in “Encyclopedia of materials science and engineering,” edited by M. Bever, Pergamon Press, Oxford, 5, 3799 (1986).      

Home