In cooperation with the Iranian Nuclear Society

Document Type : Research Paper

Authors

Abstract

Recent advances in radiation therapy have made obvious the need for dosimeters that can measure three-dimensional (3-D) dose distributions. Currently, radiosensitive gel dosimeters have provided 3-D dose measurements using the MRI technique. However, this method has some limitations. Recently, a novel transparent polymer dosimeter, PRESAGE, has been introduced which exhibits a radiochromic response when exposed to ionizing radiation. This dosimetry technique has some advantages compared with other gel dosimeters. In this study, the dose response, linearity, sensitivity, and stability of this type of dosimeter were investigated for different levels of the activator, and leuco dye concentration. In this regard, the PRESAGE dosimeters were made with different formulations and were irradiated by gamma-rays of Cobalt-60 in the dose range of 0-50 Gy. Then, the optical absorption changes of the dosimeters were measured by a spectrophotometer over a period of 14 days after the irradiation. The results indicated that increasing the activator concentration leads to the increase of the sensitivity, but decreases the stability of the dosimeter response. Furthermore, it was noted that the dosimeter shows a linear response to the radiation dose with a high level of correlation (R2>0.99).
 

Highlights

 

 

  1. 1.    S. Webb, “Intensity-modulated radiation therapy,” IOP Publishing, Bristol (2001).

 

  1. 2.    F.M. Khan, “The physics of radiation therapy,” William and Wilkins, Maryland (2003).

 

  1. 3.    J.C. Gore, Y.S. Kang, R.J. Schulz, “Measurement of radiation dose distribution by nuclear magnetic (NMR) imaging,” Phys. Med. Biol. 10, 1189-1197 (1984).

 

  1. 4.    M.J. Maryanski, R.J. Schulz, G.S. Ibbott, J.C. Gatenby, J. Xie, D. Horton, J.C. Gore, “Magnetic resonance imaging of radiation dose distributions using a polymer-gel dosimeter,” Phys. Med. Biol. 39, 1437-1455 (1994).

 

  1. 5.    Y. De Deene, C. De Wagter, B. Van Duyse, S. Derycke, B. Mersseman, W. De Gersem, T. Voet, E. Achten, W. De Neve, “Validations of MR-based polymer gel dosimetry as a preclinical three-dimensional verification tool in conformal radiotherapy,” Magn. Reson. Med. 43, 116-125(2000).

 

  1. 6.    P. Haraldsson, S.A.J. Back, P. Magnusson, L.E. Olsson, “Dose response characteristics and basic dose distribution data for a polymerization-based dosemeter gel evaluated using MR,” Br. J. Radiol. 73, 58-65 (2000).

 

  1. 7.    J.J. Novotny, V. Spevacek, P. Dvorak, J. Novotny, T. Cechak, “Energy and dose rate dependence of BANG-2 polymer-gel dosimeter,” Med. Phys. 28, 2379-2386 (2001).

 

 

 

 

  1. 8.    Y. De Deene, C. Hurley, A. Venning, K. Vergote, M. Mather, B.J. Healy, C. Baldock, “A basic study of some normoxic polymer gel dosimeters,” Phys. Med. Biol. 47, 3441-3463 (2002).

 

  1. 9.    Y. De Deene, A. Venning, C. Hurley, B.J. Healy, C. Baldock, “Dose-response stability and integrity of the dose distribution of various polymer gel dosimeters,” Phys. Med. Biol. 47, 2459-2470 (2002).

 

10. Y. De Deene, K. Vergote, C. Claeys, C. De Wagter, “The fundamental radiation properties of normoxic polymer gel dosimeters: a comparison between a methacrylic acid based gel and acrylamide based gels,” Phys. Med. Biol. 51, 653–673 (2006).

 

11. J. Adamovics, M.J. Maryanski, “A new approach to radiochromic three-dimensional dosimetry-polyurethane,” Third International Conference on Radiotherapy Gel Dosimetry, Journal of Physics, Conference Series 3, 172–175 (2004).

 

12. P.Y. Guo, J. Adamovics, M. Oldham, “Characterization of a new radiochromic three-dimensional dosimeter,” Med. Phys. 33, 1338-1345 (2006).

 

13. J. Adamovics, M.J. Maryanski, “Characterization of PRESAGE: a new 3-D radiochromic solid polymer dosimeter for ionizing radiation,” Radiat. Prot. Dosim. 120, 107–112 (2006).

Keywords

  1.  

     

    1. 1.    S. Webb, “Intensity-modulated radiation therapy,” IOP Publishing, Bristol (2001).

     

    1. 2.    F.M. Khan, “The physics of radiation therapy,” William and Wilkins, Maryland (2003).

     

    1. 3.    J.C. Gore, Y.S. Kang, R.J. Schulz, “Measurement of radiation dose distribution by nuclear magnetic (NMR) imaging,” Phys. Med. Biol. 10, 1189-1197 (1984).

     

    1. 4.    M.J. Maryanski, R.J. Schulz, G.S. Ibbott, J.C. Gatenby, J. Xie, D. Horton, J.C. Gore, “Magnetic resonance imaging of radiation dose distributions using a polymer-gel dosimeter,” Phys. Med. Biol. 39, 1437-1455 (1994).

     

    1. 5.    Y. De Deene, C. De Wagter, B. Van Duyse, S. Derycke, B. Mersseman, W. De Gersem, T. Voet, E. Achten, W. De Neve, “Validations of MR-based polymer gel dosimetry as a preclinical three-dimensional verification tool in conformal radiotherapy,” Magn. Reson. Med. 43, 116-125(2000).

     

    1. 6.    P. Haraldsson, S.A.J. Back, P. Magnusson, L.E. Olsson, “Dose response characteristics and basic dose distribution data for a polymerization-based dosemeter gel evaluated using MR,” Br. J. Radiol. 73, 58-65 (2000).

     

    1. 7.    J.J. Novotny, V. Spevacek, P. Dvorak, J. Novotny, T. Cechak, “Energy and dose rate dependence of BANG-2 polymer-gel dosimeter,” Med. Phys. 28, 2379-2386 (2001).

     

     

     

     

    1. 8.    Y. De Deene, C. Hurley, A. Venning, K. Vergote, M. Mather, B.J. Healy, C. Baldock, “A basic study of some normoxic polymer gel dosimeters,” Phys. Med. Biol. 47, 3441-3463 (2002).

     

    1. 9.    Y. De Deene, A. Venning, C. Hurley, B.J. Healy, C. Baldock, “Dose-response stability and integrity of the dose distribution of various polymer gel dosimeters,” Phys. Med. Biol. 47, 2459-2470 (2002).

     

    10. Y. De Deene, K. Vergote, C. Claeys, C. De Wagter, “The fundamental radiation properties of normoxic polymer gel dosimeters: a comparison between a methacrylic acid based gel and acrylamide based gels,” Phys. Med. Biol. 51, 653–673 (2006).

     

    11. J. Adamovics, M.J. Maryanski, “A new approach to radiochromic three-dimensional dosimetry-polyurethane,” Third International Conference on Radiotherapy Gel Dosimetry, Journal of Physics, Conference Series 3, 172–175 (2004).

     

    12. P.Y. Guo, J. Adamovics, M. Oldham, “Characterization of a new radiochromic three-dimensional dosimeter,” Med. Phys. 33, 1338-1345 (2006).

     

    13. J. Adamovics, M.J. Maryanski, “Characterization of PRESAGE: a new 3-D radiochromic solid polymer dosimeter for ionizing radiation,” Radiat. Prot. Dosim. 120, 107–112 (2006).