Journal of Nuclear Science, Engineering and Technology (JONSAT)
In cooperation with the Iranian Nuclear Society

Selection of Suitable Reaction and Determination of Irradiation Parameters for Palladium-103 Production

Document Type : Research Paper

Authors

M Sadeghi
H Afarideh
M.R Ensaf
N Shadan pour
M Kiyomarsi
Abstract
To benefit greatly from 103Rh(p,n)103Pd cross section curve and to avoid formation of radionuclide 101Pd impurity, the proton incident and exit energy of 18 and 5 MeV, must be considered, using ALICE code and experimental results. According to SRIM code, the Rh thickness must be 480µm for 90º beam/target angle geometry. To minimize the thickness of the rhodium layer, and hence to reduce the price of rhodium target, the angle of beam target has been adgusted to 6 degrees so as to decrease the thickness to 48µm

Highlights

  1. 1.    M.D. Porrazzo, S. Michael, “Permanent interstitial implantation using palladium-103: The New York Medical College Preliminary Experience,” J. Radiation Oncology Biology Physics, 23(5), 1033-1036 (1992).

 

  1. 2.    S. Nag, M. Riborich, J.Z. Cai, “Palladium-103 vs. Iodine-125 brachytherapy in the Danning-PAP rat prostate tumor,” Endocuriether/Hyperthem. Oncol. 12, 119–124 (1996).

 

  1. 3.    S. Nag, P.J. Sweeney, M.G. Wientjes, “Dose–response study of iodine-125 and palladium-103 brachytherapy in a rat prostate tumor (Nb AI-1),” Endocuriether/Hyperthem. Oncol. 9, 97–104 (1993).

 

  1. 4.    J.L. Carden Jr, Ga. Tucker, United States Patent. Patent Number: 5405309 (1995).

 

  1. 5.    M. Fassbender, F.M. Nortier, I.W. Schroeder, T.N. van der Walt, “The production of 103Pd via the natAg(p,x)103Pd nuclear process,” Radiochim. Acta, 87 (1999).

 

  1. 6.    A. Hermanne, M. Sonck, A. Fenyvesi, L. Daraban, “Study on production of 103Pd and characterization of possible contaminants in the proton irradiation of 103Rh up to 28 MeV,” Nucl. Inst. & Meth. Phys. Res. B, 170, 281-299 (2000).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  1. 7.    S. Sudár, F. Cserpak, S.M. Qaim, “Measurements and nuclear model calculations on proton induced reactions on 103Rh up to 40 MeV: evaluation of the excitation function of the 103Rh(p,n)103Pd reaction relevant to the production of the therapeutic radionuclide 103Pd,” Appl. Radiat. Isot. 56, 821 (2002).

 

  1. 8.    Ch. Zhang, Y. Wang, Y. Zhang, X. Zhang, “Cyclotron production of no-carrier-added palladium-103 by bombardment of rhodium-103 target,” Appl. Radiat. Isot. 55, 441-445 (2000).

 

  1. 9.    A. Hermanne, M. Sonck, S. Takacs, F. Tarkanyi, Y. Shubin, “Study on alternative production of 103Pd and characterisation of contaminants in the deuteron irradiation of 103Rh up to 21 MeV,” Nucl. Inst. Meth. Phys. Res. B, 187, 3–14 (2002).

 

  1. 10.          P.V. Harper, K. Lathrop, J.L. Need, “The thick target yield and excitation function for the reaction 103Rh(p,n)103Pd,” ORNL-LR-DWG 51564 124 (1961).

 

  1. 11.          P.P. Dmitriev, Radionuclide yield in reactions with protons, deuterons, alpha particles and helium-3, INDC(CCP)-263/G+CN+SZ, Vienna (1986).

 

  1. 12.              S. Mukhammedov, A. Vasidov, E. Pardaev, “Application of proton and neutron activation method of analysis for the determination of elements with Z greater 42,” Atomnaya Energia, 56.50 (1984).

Keywords

Palladium-103
Excitation Function
Stopping Power
Cyclotron
Cross Section
ALICE Code
SRIM Code
  1. 1.    M.D. Porrazzo, S. Michael, “Permanent interstitial implantation using palladium-103: The New York Medical College Preliminary Experience,” J. Radiation Oncology Biology Physics, 23(5), 1033-1036 (1992).

 

  1. 2.    S. Nag, M. Riborich, J.Z. Cai, “Palladium-103 vs. Iodine-125 brachytherapy in the Danning-PAP rat prostate tumor,” Endocuriether/Hyperthem. Oncol. 12, 119–124 (1996).

 

  1. 3.    S. Nag, P.J. Sweeney, M.G. Wientjes, “Dose–response study of iodine-125 and palladium-103 brachytherapy in a rat prostate tumor (Nb AI-1),” Endocuriether/Hyperthem. Oncol. 9, 97–104 (1993).

 

  1. 4.    J.L. Carden Jr, Ga. Tucker, United States Patent. Patent Number: 5405309 (1995).

 

  1. 5.    M. Fassbender, F.M. Nortier, I.W. Schroeder, T.N. van der Walt, “The production of 103Pd via the natAg(p,x)103Pd nuclear process,” Radiochim. Acta, 87 (1999).

 

  1. 6.    A. Hermanne, M. Sonck, A. Fenyvesi, L. Daraban, “Study on production of 103Pd and characterization of possible contaminants in the proton irradiation of 103Rh up to 28 MeV,” Nucl. Inst. & Meth. Phys. Res. B, 170, 281-299 (2000).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  1. 7.    S. Sudár, F. Cserpak, S.M. Qaim, “Measurements and nuclear model calculations on proton induced reactions on 103Rh up to 40 MeV: evaluation of the excitation function of the 103Rh(p,n)103Pd reaction relevant to the production of the therapeutic radionuclide 103Pd,” Appl. Radiat. Isot. 56, 821 (2002).

 

  1. 8.    Ch. Zhang, Y. Wang, Y. Zhang, X. Zhang, “Cyclotron production of no-carrier-added palladium-103 by bombardment of rhodium-103 target,” Appl. Radiat. Isot. 55, 441-445 (2000).

 

  1. 9.    A. Hermanne, M. Sonck, S. Takacs, F. Tarkanyi, Y. Shubin, “Study on alternative production of 103Pd and characterisation of contaminants in the deuteron irradiation of 103Rh up to 21 MeV,” Nucl. Inst. Meth. Phys. Res. B, 187, 3–14 (2002).

 

  1. 10.          P.V. Harper, K. Lathrop, J.L. Need, “The thick target yield and excitation function for the reaction 103Rh(p,n)103Pd,” ORNL-LR-DWG 51564 124 (1961).

 

  1. 11.          P.P. Dmitriev, Radionuclide yield in reactions with protons, deuterons, alpha particles and helium-3, INDC(CCP)-263/G+CN+SZ, Vienna (1986).

 

  1. 12.              S. Mukhammedov, A. Vasidov, E. Pardaev, “Application of proton and neutron activation method of analysis for the determination of elements with Z greater 42,” Atomnaya Energia, 56.50 (1984).

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