مجله علوم، مهندسی و فناوری هسته‌ای

بررسی تأثیر تابش باریکه‌ی الکترونی بر اسپایک‌های سارس کووید2، مرس کووید، یوکی کووید، سارس کووید با استفاده از ابزار Geant4-DNA

نوع مقاله : مقاله پژوهشی

نویسندگان

مهرداد جلیلی ترکمانی 1
فرهاد ذوالفققارپور 1
اسداله اسدی 2
پونه سیاح کوهی 1

1 گروه فیزیک، دانشکده علوم، دانشگاه محقق اردبیلی، صندوق پستی: 5619913131، اردبیل- ایران

2 گروه زیست شناسی، دانشکده علوم، دانشگاه محقق اردبیلی، صندوق پستی: 5619913131 ، اردبیل- ایران

https://doi.org/10.24200/nst.2022.1003.1680
چکیده
انتقال ویروس کرونا به داخل سلول از طریق اسپایک‌های ویروس انجام می‌شود پس یکی از بهترین راه‌های مقابله با انتقال ویروس به داخل سلول‌های بدن، ایجاد اختلال در روند عملکرد اسپایک‌های ویروس است. بنابراین در این تحقیق، چگونگی جذب و انتقال انرژی از طریق پرتوهای رادیواکتیو به اسپایک‌های سارس کووید2، مرس کووید، یوکی کووید و سارس کووید توسط ابزار جینت4- دی اِن اِی شبیه‌سازی شده و نتایج حاصل از پرتودهی این اسپایک‌ها با یکدیگر مقایسه شده است. از آن‌جایی که یکی از عوامل کاهش در ماندگاری ویروس جذب انرژی توسط ویروس می‌باشد، در این پژوهش سعی شده است با انجام شبیه‌سازی با پرتودهی اسپایک این ویروس­‌ها به‌وسیله باریکه الکترونی با گستره‌ی انرژی keV 2 -eV  10 مقادیر جذب انرژی استخراج و رابطه‌ آن با آمار مبتلایان و قربانیان گونه‌های شایع کرونا مقایسه گردد. نتایج حاصل شده نشان می‌­دهد که ارتباط معکوسی بین میزان انرژی جذب شده در اسپایک‌­ها و تلفات انسانی وجود دارد.

کلیدواژه‌ها

جینت4- دی اِن اِی
سارس کووید2
مرس کووید
یوکی کووید
باریکه‌ی الکترونی

عنوان مقاله English

Investigation of electron beam irradiation effect on spikes of SARS-COV2, MERS-COV, UK variant, SARS-COV by Geant4-DNA toolkit

نویسندگان English

M. Jalili Torkamani 1
F. Zolfagharpour 1
A. Asadi 2
P. Sayyahkoohi 1
1 Department of Physics, Faculty of Science, University of Mohaghegh Ardabili, P.O.BOX: 5619913131, Ardabil – Iran
2 Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, P.O.BOX: 561991313, Ardabil, Iran
چکیده English

Viruses pass cell walls and enter cells using their spikes, So one of the efficient ways to stop viral infections is to disturb their spikes functionality. In this research, the process of energy absorption and transfer by SARS-COV2, MERS-COV, UK-COV, and SARS-COV spikes was studied. In this research sample viruses exposed to radioactive radiations and results were compared by Geant4-DNA and analyzed. A strategy to reduce the virus life cycle is energy absorption. In this research, the response to viruses spikes to radiation was simulated. Samples were exposed to 10 eV–2 keV electron beams. The level of Energy absorption and its relation to the number of infected patients was studied. It was concluded there is an inverse relationship between absorbed energy level and patient death.

کلیدواژه‌ها English

Geant4-DNA
SARS-COV2
MERS-COV
UK-COV
Electron beam
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