مجله علوم، مهندسی و فناوری هسته‌ای

امکان‌سنجی تولید رادیونوکلئید پزشکی برم-76 با استفاده از یون سنگین Li+7

نوع مقاله : مقاله پژوهشی

نویسندگان

علی جمشیدی
مهیار نیروئی

گروه مهندسی پرتوپزشکی، دانشکده فنی و مهندسی، واحد لاهیجان، دانشگاه آزاد اسلامی، صندوق پستی: 1616، لاهیجان - ایران

https://doi.org/10.24200/nst.2024.1570
چکیده
برم-76 (نیمه‌عمر 2/16 ساعت) رادیونوکلئیدی پوزیترون‌زا است که پتانسیل بالایی برای استفاده در پزشکی هسته‌ای دارد؛ اما به دلیل دشواری تولید مقادیر تجاری آن، فقط در مطالعات آزمایشگاهی استفاده می‌شود. این رادیونوکلئید معمولاً از طریق واکنش Br76Se(p,n)76 تولید می‌شود. هدف از این تحقیق، بررسی امکان تولید تجاری Br76 از طریق بمباران هدف‌هایی از جنس ایزوتوپ‌های پایدار ژرمانیم با یون سنگین Li+7 است. با استفاده از کدهای مونت‌کارلو EMPIRE و LISEcute++، توابع برانگیختگی واکنش‌های Br76Li+,n)7)Ge70، Br76n)3Li+, 7)Ge72، Br76n)4Li+, 7)Ge73، Br76n)5Li+, 7)Ge74 و Br76n)7Li+, 7)Ge76 رسم شده و از مقایسه این توابع برانگیختگی، واکنش Br76n)3Li+, 7)Ge72 در محدوده انرژی 30 تا 40 مگاالکترون‌ولت به‌عنوان واکنش برتر انتخاب شد. بیشینه بهره تولید تئوری در انرژی 40 مگاالکترون‌ولت برای این کدها به ترتیب MBq/µAh 46/32 و MBq/µAh 43/61 است. بهره تئوری و تجربی واکنش Br76p,n))Se76 در انرژی 16 مگاالکترون‌ولت به ترتیب MBq/µAh 61/506 و MBq/µAh 88 است. از مقایسه بهره تولید تئوری واکنش‎های Br76n)3Li+, 7)Ge72 و Br76Se(p,n)76 می‌توان این نتیجه را گرفت که واکنش Br76n)3Li+, 7)Ge72 تنها زمانی مورد توجه قرار می‌گیرد که هدف Ge72 یا ترکیبی از آن قابلیت پرتوگیری طولانی‌مدت (بدون ذوب شدن) را داشته باشد و از این طریق، اکتیویته Br76 بیش­تری را در عمل تولید کند.

کلیدواژه‌ها

برم-76
ژرمانیم
سلنیم-76
شبیه‌سازی مونت‌کارلو
بهره تولید

عنوان مقاله English

Feasibility of bromine-76 medical radionuclide production by 7Li+ heavy ion

نویسندگان English

A. Jamshidi
M. Nirouei
Department of Radiological Engineering, Faculty of Engineering, Lahijan Branch, Islamic Azad University, P.O.Box: 1616, Lahijan - Iran
چکیده English

Bromine-76 (half-life = 16.2 hours) is a positron emitter radionuclide with a high potential for use in nuclear medicine; but due to the difficulty of producing commercial quantities, it is only used in laboratory studies. This radionuclide is usually produced through the reaction of 76Se(p,n)76Br. This research investigates the possibility of obtaining commercial quantities of 76Br by bombarding targets made of stable germanium isotopes with 7Li+ heavy ion. The excitation functions of 70Ge(7Li+,n)76Br, 72Ge(7Li+,3n)76Br, 73Ge(7Li+,4n)76Br, 74Ge(7Li+,5n)76Br and 76Ge(7Li+,7n)76Br reactions were drawn using the EMPIRE and LISEcute++ codes. From the comparison of these excitation functions, 72Ge(7Li+,3n)76Br in the energy range of 30 to 40MeV was selected as the premier reaction. The maximum theoretical production yield in 40MeV for these codes is 32.46MBq/µAh and 61.43MBq/µAh, respectively. The analyzed and experimental yields of 76Se(p,n)76Br at 16MeV are 506.61MBq/µAh and 88MBq/µAh, respectively. From the comparison of the theoretical production yield of 72Ge(7Li+,3n)76Br and 76Se(p,n)76Br reactions, it can be concluded that the 72Ge(7Li+,3n)76Br reaction is considered only when the target of 72Ge or a combination of them have long-term irradiation capability (without melting) and thus produce more 76Br activity in practice.

کلیدواژه‌ها English

Bromine-76
Germanium
Selenium-76
Monte Carlo simulation
Production yield
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