مجله علوم، مهندسی و فناوری هسته‌ای

شبیه‌سازی اثر تغییر دز حاصل از حضور نانوذرات فلزی مختلف تحت تابش پروتون با استفاده از ابزار Geant4

نوع مقاله : مقاله پژوهشی

نویسندگان

جعفر عالم‌گیر 1
سیدابوالفضل حسینی 1
احسان سلیمی 2

1 دانشکده مهندسی انرژی، دانشگاه صنعتی شریف، صندوق پستی: 1114- 14565، تهران- ایران

2 پژوهشگاه دانش‌های بنیادی، صندوق پستی: 5531 - 19395، تهران- ایران

https://doi.org/10.24200/nst.2024.1574
چکیده
در چند دهه اخیر، تأثیر نانوذرات در پرتودرمانی موردتوجه بسیاری از محققان قرار گرفته است. پژوهش حاضر با هدف بررسی اثر مدل‌های برهم­کنش فیزیکی مختلف بر روی محاسبات دز در اطراف نانوذرات طلا، هافنیوم و گادولینیم، انجام شده است. با استفاده از ابزار مونت‌کارلوی Geant4، یک نانوذره به قطر 50 نانومتر در فانتوم مکعبی آب شبیه‌سازی شد و تحت تابش پروتون با انرژی‌های 5، 50 و MeV 150 قرار گرفت. مطالعه حاضر پارامترهای مختلفی را از جمله طیف انرژی الکترون‌ها و فوتون‌های ثانویه، توزیع دز شعاعی (RDD)، ضریب افزایش دز (DEF)، در اطراف نانوذره با سه جنس مختلف و دو مدل برهم­کنش فیزیکی مورد بررسی قرار داده است. نتایج حاصل‌شده نشان داد که برای نانوذره طلا تعداد الکترون‌های ثانویه با مدل پنلوپه بیش­تر از مدل لیورمور بود؛ ولی برای دو نانوذره دیگر، الکترون‌های ثانویه بیش­تری با مدل لیومور نسبت به مدل پنلوپه تولید شد. در نمودارهای RDD تا فاصله 6 نانومتری از سطح نانوذره طلا (در راستای شعاعی در محیط آب)، مدل پنلوپه یک اختلاف 10 درصدی را نسبت به مدل لیورمور ارائه می‌کند. هم­چنین، تا فاصله 9 نانومتری از سطح نانوذره، مدل لیورمور به ترتیب یک افزایش 16 و 10 درصدی در دز را در مقایسه با مدل پنلوپه برای نانوذرات هافنیوم و گادولینیم نشان می‌دهد. در مورد DEF، دز نهشت‌شده در اطراف نانوذره طلا 14 برابر افزایش یافت که بالاترین مقدار در مقایسه با افزایش دز پیرامون نانوذرات هافنیوم و گادولینیم که به ترتیب 10 و 6 برابر بودند، می‌باشد.

کلیدواژه‌ها

نانوذرات
ضریب افزایش دز
پروتون‌درمانی
شبیه‌سازی مونت‌کارلو
Geant4

عنوان مقاله English

The simulation of dose variation effects due to the presence of different metal nanoparticles under proton irradiation using Geant4 toolkit

نویسندگان English

J. Alamgir 1
S.A. Hosseini 1
E. Salimi 2
1 Department of Energy Engineering, Sharif University of Technology, P.O.Box: 14565-1114, Tehran – Iran
2 Institute for Research in Fundamental Sciences, IPM, P.O.Box: 19395-5531, Tehran, Iran
چکیده English

The impacts of nanoparticles in radiation therapy have been investigated for many years now. The present study was conducted to investigate the effect of different physical interaction models on dose calculations using gold, hafnium and gadolinium nanoparticles. A nanoparticle with a diameter of 50 nm was simulated in a cubic water phantom. It was irradiated by protons with energies of 5, 50 and 150 MeV using Geant4 Monte Carlo toolkit. The current study considers various parameters, including the energy spectrum of secondary electrons and photons, radial dose distribution (RDD), dose enhancement factor (DEF), around the nanoparticle with three different materials and two physical interaction models. The obtained data showed that for gold nanoparticles, the Penelope model generated a greater number of secondary electrons than the Livermore model; however, for the other two nanoparticles, the Livermore model produced a greater number of secondary electrons than the Penelope model. In the RDD graphs, the Penelope model presents a 10% difference compared to the Livermore model up to a distance of 6 nm from the nanoparticle’s surface (along the radial axis in water). Furthermore, the Livermore model indicates a 16% and 10% increase in dose compared to the Penelope model. This is up to a distance of 9 nm from the surface of hafnium and gadolinium nanoparticles, respectively. In the case of DEF, the dose deposited around the gold nanoparticle was increased by 14. This is the highest amount in comparison to DEF of hafnium and gadolinium nanoparticles which is 10 and 6, respectively.

کلیدواژه‌ها English

Nanoparticle
Dose enhancement factor
Proton therapy
Monte carlo simulation
Geant4
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