نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه فیزیک اتمی مولکولی، دانشکده فیزیک، دانشگاه الزهرا
2 پژوهشکده فوتونیک و فناوری های کوانتومی. پژوهشگاه علوم و فنون هسته ای
3 پژوهشکده علوم و فناوری اپتیک و لیزر، دانشگاه صنعتی مالک اشتر
کلیدواژه‌ها
موضوعات
عنوان مقاله English
نویسندگان English
In this study, the accurate diagnosis and differentiation of healthy and cancerous brain tissues was investigated using laser fluorescence imaging guided by the sodium fluorescein exogenous fluorophore and the results are compared with tissues auto-fluorescence images. Samples, which were diagnosed as meningioma, metastatic carcinoma, low-grade glioma, as well as high-grade glioma types by pathologists, were obtained from 4 patients and optical imaging technique with hematoxylin-eosin staining is used to validate the results. The findings reveal that the intensity of fluorescence radiation from cancerous tissues is more intense than that from healthy tissues due to the greater permeability of the dye in the cavities and pores of the tissue. In addition to increasing the accuracy and precision of the results, this imaging method allows the surgeon to visualize and diagnose the tumor in real-time and completely resect the tumor, eliminating the need for invasive biopsies. Therefore, the results indicate that sodium fluorescein can be used as a reliable fluorescence marker in intraoperative imaging to improve the diagnosis and delineation of brain tumors.
کلیدواژه‌ها English
